Spithridates (Greek: Σπιθριδάτης; fl. 365–334 BC) was a Persian satrap of Lydia and Ionia under the high king Darius III Codomannus.
He was one of the Persian commanders at the Battle of the Granicus, in 334 BC. In this engagement, while he was aiming a blow
from behind at Alexander the Great, his arm was cut off by Cleitus the Black and he subsequently died.